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. 2021 Mar 17;12(4):282. doi: 10.1038/s41419-021-03556-4

Fig. 4. miR-34a inhibits the translation of CD47/PD-L1 mRNA through targeting the 3′UTR of the CD47/PD-L1.

Fig. 4

A, B The seed region of miR-34a has a highly complementary sequence to the 3′UTR of CD47/PD-L1. C, D Luciferase reporter assays were performed in HEK-293T and SiHa cells with co-transfection of the negative control, wild-type, or mutant 3′UTR constructs and mimic NC or miR-34a mimic (n = 3 per group). Each experiment was repeated twice. N.S. not significant, **p < 0.01; ***p < 0.001; ****p < 0.0001.