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. 2021 Mar 4;9:641271. doi: 10.3389/fcell.2021.641271

FIGURE 5.

FIGURE 5

CDK9i treatment alters the expression of metabolic enzymes in B-ALL cells. (A) Heatmap of glycolysis-related genes in REH cells analyzed by RNA-seq. (B–D) Relative mRNA expression levels of GLUT1, HK2, and LDHA measured by qRT-PCR in NALM6 and REH cells after treatment with SNS-032 for 24 h. (E) Protein expression levels of GLUT1, HK2, and LDHA in B-ALL cells detected by Western blot analysis after treatment with SNS-032 for 24 h. (F) Protein expression levels of GLUT1, HK2, and LDHA in NALM6 and REH cells detected by Western blot after treatment with AZD4573 for 24 h. Values were shown as mean ± SEM. ∗p < 0.05.