Table 3.
Mean DNA methylation prior to NEC onset.
| LBN | SBN | NEC (LBN + SBN) | Control | |
|---|---|---|---|---|
| EPO | n = 5 | n = 14 | n = 19 | n = 40 |
| Mean methylation | 3.0 (2.4–3.2) | 2.2 (2.0–2.8) | 2.3 (2.0–2.9) | 2.9 (2.0–4.0) |
| VEGFA | n = 5 | n = 14 | n = 19 | n = 42 |
| Mean methylation | 1.6 (0.9–1.7) | 1.6 (1.5–2.2) | 1.6 (1.4–2.1) | 1.7 (1.2–2.4) |
| DEFA5 | n = 4 | n = 9 | n = 13 | n = 26 |
| Mean methylation | 71.7 (69.6–73.9) | 75.5 (72.6–77.6) | 73.5 (72.2–76.3) | 73.5 (71.9–77.1) |
| ENOS | n = 5 | n = 13 | n = 18 | n = 39 |
| Mean methylation | 96.9 (95.8–100.0) | 94.8 (92.2–98.7) | 96.4 (92.2–98.9) | 93.8 (87.5–99.0) |
| TLR4 | n = 3 | n = 12 | n = 15 | n = 36 |
| Mean methylation | 67.1 (66.1–78.6) | 79.8 (76.5–84.2) | 78.9 (75.8−84.2) | 76.0 (67.7–83.0) |
Values shown as median and (IQR). NEC, Necrotizing Enterocolitis; LBN, Long Before NEC; SBN, a Short time Before NEC; NB: The LBN and SBN group were combined before comparison with the control group, and not compared separately with the control group in the prior to NEC analysis.