Table 2.
Major Phase III Trials Comparing Laparoscopic Surgery with Open Surgery for Gastric Cancer.
| Trial name | Published
year |
No. of
patients |
Eligible
patients |
Treatment
groups |
Morbidity
(%) |
P-value | Mortality
(%) |
P-value |
|---|---|---|---|---|---|---|---|---|
| JCOG0912 (30) | 2017 | 921 | cStage IA/IB | ODG
LDG |
3.7
3.3 |
0.72 | 0
0 |
- |
| KLASS-01 (31), (32) | 2015, 2016 | 1416 | cStage IA/IB | ODG
LDG |
19.9
13.0 |
0.001 | 0.3
0.6 |
0.450 |
| JLSSG0901 (33) | 2017 | 507 | cT2-T4a | ODG
LDG |
4.7
3.1 |
0.285 | 0.4
0.4 |
1.000 |
| KLASS-02 (34) | 2016 | 1050 | cT2-4a N0-1 | ODG
LDG |
24.3
16.4 |
0.002 | 0.6
0.4 |
0.683 |
| CLASS-01 (35) | 2018 | 1056 | cT2-T4a | ODG
LDG |
15.2
12.9 |
0.285 | 0.4
0 |
0.249 |
Abbreviations: ODG, open distal gastrectomy; LDG, laparoscopic distal gastrectomy.