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. 2021 Mar 4;11:599124. doi: 10.3389/fonc.2021.599124

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Copyright © 2021 Zhu, Li, Zhang, Zhu, Liu, Lin, Hu, Zhou, Ren and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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siah2 is essential for autophagic degradation of ZEB1 in HMGB1 deficient cells. (A) Identification of the ZEB1-siah2 interaction or HIPK2-siah2 interaction in HCC cells by co-immunoprecipitation. Endogenous ZEB1 or HIPK2 was pulled down with anti-siah2 and endogenous siah2 was pulled down with anti-ZEB1, compared with IgG, and vice versa and detected by immunoblotting. (B) Role of siah2 in ZEB1 decrease in shHMGB1 cells was determined by transfection with siah2 siRNA (sisiah2).