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. 2021 Mar 4;15:646538. doi: 10.3389/fnins.2021.646538

FIGURE 2.

FIGURE 2

Altered rs-FC in MwoA patients and the correlation matrices of edges and clinical symptoms. (A) Compared with HCs, MwoA patients manifested lower rs-FC in edges between INS and SFGdor, SPG, ANG; and edges between SPG and IPL, SMG. MwoA patients showed higher rs-FC edges between ANG and SFG.dor, MFG, IPL; and edges between bilateral ACC. (uncorrected p-value lower than 0.05). (B) There were significantly lower rs-FC edges between the SFGdor.L and INS.L compared with HCs. And significantly higher rs-FC edge between the dlPFC.L and bilateral ANG than HCs. The boxplot showed the distribution of rs-FC values within and between-group. (C) The edges between ANG and SFGdor were significantly higher than HCs, and an edge between SFGdor and INS was significantly lower in MwoA conditions. (FDR-corrected p-value lower than 0.05) (D) The correlation matrix showed no significant correlation between significantly altered FC edge and headache duration, frequency, SAS, and SDS. (E) Six edges significantly correlated with headache intensity, four edges significantly correlated with headache frequency, five edges significantly correlated with headache duration, 12 edges significantly correlated with SAS, and six edges significantly correlated with SDS. rs-FC, resting-state functional connectivity; L, left hemisphere; R, right hemisphere; SFGdor, dorsolateral superior frontal gyrus; MFG, middle frontal gyrus; INS, insula; ACG, anterior cingulate gyri; SPG, superior parietal gyrus; IPL, inferior parietal gyrus; SMG, supramarginal gyrus; ANG, angular gyrus; HI, headache intensity; HD, headache duration; HF, headache frequency; SAS, Zung self-rating anxiety scale; SDS, Zung self-rating depression scale.