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. 2021 Mar 4;15:646538. doi: 10.3389/fnins.2021.646538

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Copyright © 2021 Tian, Yin, Xiao, Dong, Yang, Wang, Ha, Chen, Liang, Zeng and Lan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Moderation effect module diagram and simple slope test results. (A) The conceptual diagram and statistical diagram of the moderator variable (resting-state functional connectivity edge between SFGdor.L and ANG.L) moderated the link between the edge (ACG.L – IPL.R) and headache intensity. A Johnson-Neyman output plot of the edge (SFGdor.L – ANG.L) indirect effect on the link between the normal edge (ACG.L – IPL.R) and headache intensity. (B) The conceptual diagram and statistical diagram of the interaction moderated the link between the edge (MFG.R – ACG.L) with headache intensity. A Johnson-Neyman output plot of the edge (SFGdor.L – ANG.L) indirect effect on the link between the normal edge (MFG.R – ACG.L) and headache intensity. The horizontal line denotes an indirect effect of zero. The vertical line represents the boundary of the region of significance. rs-FC, resting state-functional connectivity; L, left hemisphere; R, right hemisphere; SFGdor, dorsolateral superior frontal gyrus; ANG, angular gyrus; MFG, middle frontal gyrus; ACG, anterior cingulate and paracingulate gyri; IPL, inferior parietal gyrus.