TABLE 5.
Natural drugs used to treat epilepsy by regulating glial cells.
| Natural drugs | Compounds | Chemical structure | Animal models | Mechanisms | References |
|---|---|---|---|---|---|
| Nandina domestica Thunb (Berberidaceae) | Amentoflavone |
|
L&PS in rats | Inhibition of microglial activation and reactive proliferation of astrocytes | Reng et al. (2020) |
| Glycyrrhiza glabra L. (Fabaceae) | Carbenoxolone |
|
Rat model of ferric ion-induced posttraumatic epilepsy | Reduced cortical glial fibrillary acidic protein and connexin 43 expression | Chen et al. (2013) |
| Panax quinquefolius L. (Araliaceae) | Ginsenoside Rb3 |
|
L&PS in rats | Inhibiting microglial cell activation and polarization | Kim and Rhim (2004) |
| Tripterygium wilfordii Hook F.(Celastraceae) | Triptolide |
|
KAS in microglia | Inhabiting expression of IIMHC II | Sun et al. (2018) |
| Acorus tatarinowii Schott (Araceae) | α-asarone |
|
PTZS in rats | Inhibiting microglia cell activation in rat brain tissue | Yuan and Liu (2020) |
IIMHC, major histocompatibility complex class; L&PS, Lithium & pilocarpine induced seizure.