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. 2021 Mar 17;11:6151. doi: 10.1038/s41598-021-85625-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pretreatment with memantine did not affect the elevation of [Ca²⁺]i induced by TNF in rodent microglial cells. (A) Five representative traces showing a treatment of 3 ng/mL TNF-induced sustained increase in [Ca²⁺]i in mouse primary microglial cells. (A, inset) The inset shows a 100 μM ATP-induced transient increase in [Ca²⁺]i in mouse primary microglial cells. The average trace of 10 [Ca²⁺]i traces in response to ATP is shown. (B) Five representative traces showing pretreatment with memantine did not affect the elevation of [Ca²⁺]i induced by TNF in mouse primary microglial cells. (C) Average traces of 5 [Ca²⁺]i traces showing a treatment of 3 ng/mL TNF-induced sustained increase in [Ca²⁺]i in mouse 6–3 microglial cells. Pretreatment with memantine did not affect the elevation of [Ca²⁺]i induced by TNF in mouse 6–3 microglial cells.