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. 2021 Mar 17;12(4):283. doi: 10.1038/s41419-021-03577-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Mice were treated 3 days with GC7 (3 mg/kg, i.p., “GC7” group) or vehicle only (NaCl, “ctrl” group) and metabolic parameters were analysed at the end of the treatment. a Glucosuria (glucose/creatinine) and lactaturia (lactate/creatinine) measured in bladder urine. b Urinary creatinine (mg/dL). c Hypusination of eIF5A and GLUT1 and GLUT2 protein levels evaluated by western blot using four kidney protein extract for each group. MW molecular weight. Graphic displayed hypusine/total eIF5A ratio and GLUT/β-actin ratio using optical density band values. d Mosaic reconstruction of whole-kidney sections from untreated and GC7-treated mice displaying GLUT1 signals in the cortical region. Magnification of a representative cortical regions from each group. Scale bars are indicated. e Quantification of GLUT1 immunofluorescence. Graphics displayed the scatter plot of 4 (c), 6 (a, b) or 10 (e) independent values and mean ± SD. *p < 0.05 evaluated using Mann–Whitney test.