Fig. 8. Schema of GC7 effects on glucose handling in proximal cells.

Schematic representation of normal and GC7-treated proximal cells regarding the glucose handling. GC7 represses the oxidative phosphorylation mediated by the mitochondrial function and enforces the cell to shift toward a glycolytic pathway to maintain energetic status. The apical flux of glucose mediated by the SGLT2 transporter is thus necessary to feed this pathway and cell survival becomes then largely independent of ambient oxygen. This reversible shift is accompanied by a strong inhibition of the glucose reabsorption through the basolateral membrane due to the downregulation of the facilitated transporter GLUT1.