Table 2.
List of selected differentially expressed genes (DEGs) of the mid-anterior intestine of juvenile gilthead seabream (Sparus aurata) fed a diet supplemented with a blend of garlic, carvacrol, and thymol essential oils (EOs).
| Gene name | Acronym | FC | P-value |
|---|---|---|---|
| PROTEOLYSIS AND DEUBIQUITINATION | |||
| UFM1 Specific Peptidase 2 | ufsp2 | 1.621 | 0.012 |
| Proteasome 20S Subunit Alpha 6 | psma6 | 1.491 | 0.014 |
| Ubiquitin Specific Peptidase 10 | usp10 | 1.490 | 0.026 |
| Proteasome 26S Subunit, ATPase 3 | psmc3 | 1.413 | 0.040 |
| Ubiquitin Specific Peptidase 48 | usp48 | 1.359 | 0.036 |
| Proteasome 20S Subunit Alpha 4 | psma4 | 1.289 | 0.027 |
| OTU Deubiquitinase 3 | otud3 | 1.256 | 0.035 |
| Ubiquitin Specific Peptidase 4 | usp4 | 1.103 | 0.007 |
| Interleukin 1 Beta | il-1β | −1.167 | 0.025 |
| NFKB Inhibitor Alpha | nfkbia | −1.327 | 0.047 |
| Proteasome 20S Subunit Beta 6 | psmb6 | −1.495 | 0.048 |
| IMMUNITY | |||
| Leukocyte Elastase Inhibitor | serpinb1 | 1.561 | 0.024 |
| Adenosine Deaminase | ada | 1.517 | 0.025 |
| Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 | prex1 | 1.478 | 0.018 |
| CD9 Molecule | cd9 | 1.283 | 0.033 |
| CD81 Molecule | cd81 | 1.279 | 0.018 |
| Perforin 1 | prf1 | 1.181 | 0.034 |
| Cathepsin B | ctsb | −1.340 | 0.031 |
| TRANSPORT AND SECRETION | |||
| Fatty Acid Binding Protein 6 | fabp6 | 2.659 | 0.044 |
| Serine Protease 3 | prss3 | 1.824 | 0.002 |
| RAB5A, Member RAS Oncogene Family | rab5a | 1.668 | 0.023 |
| RAB10, Member RAS Oncogene Family | rab10 | 1.456 | 0.030 |
| Rho GTPase Activating Protein 1 | arhgap1 | 1.363 | 0.048 |
| NRAS Proto-Oncogene, GTPase | nras | 1.257 | 0.010 |
| RAB1A, Member RAS Oncogene Family | rab1a | 1.238 | 0.025 |
| Hypoxia Inducible Factor 1 Subunit Alpha | hif1a | −1.259 | 0.002 |
| RESPONSE TO CYCLIC COMPOUNDS | |||
| Carbonic Anhydrase 2 | ca2 | 2.089 | 0.046 |
| Tribbles Pseudokinase 1 | trib1 | 1.740 | 0.011 |
| Glutathione S-Transferase Theta 2B | gstt2b | 1.456 | 0.018 |
| Cytochrome P450 Family 2 Subfamily J Member 2 | cyp2j2 | 1.284 | 0.045 |
| Growth Hormone 2 | gh2 | 1.283 | 0.032 |
| ATPase Na+/K+ Transporting Subunit Alpha 1 | atp1a1 | 1.271 | 0.022 |
| Peroxiredoxin 3 | prdx3 | −1.220 | 0.009 |
| Glutamic-Oxaloacetic Transaminase 2 | got2 | −1.254 | 0.008 |
| Adiponectin Receptor 1 | adipor1 | −1.262 | 0.041 |
| Cathepsin B | ctsb | −1.340 | 0.031 |
| SYMBIOSIS | |||
| Retinoic Acid Receptor Alpha | rara | 1.164 | 0.003 |
| Retinoid X Receptor Beta | rxrb | −1.172 | 0.030 |
| GENE EXPRESSION | |||
| Zinc Finger Protein 572 | znf572 | 1.389 | 0.019 |
| CDK5 Regulatory Subunit Associated Protein 3 | cdk5rap3 | 1.341 | 0.014 |
| Zinc Finger E-Box Binding Homeobox 2 | zeb2 | 1.315 | 0.003 |
| Heterogeneous Nuclear Ribonucleoprotein U | hnrnpu | 1.284 | 0.012 |
| Cellular Communication Network Factor 4 | wisp1 | 1.280 | 0.040 |
| NOP53 Ribosome Biogenesis Factor | gltscr2 | 1.263 | 0.034 |
| Zinc Finger Protein 74 | znf74 | 1.256 | 0.038 |
| Pre-MRNA Processing Factor 8 | prpf8 | 1.214 | 0.005 |
| Zinc Finger CCCH-Type Containing 11A | zc3h11a | 1.207 | 0.023 |
| Zinc Finger Protein 214 | znf214 | 1.201 | 0.008 |
| Small Nuclear Ribonucleoprotein U5 Subunit 200 | snrnp200 | 1.192 | 0.008 |
| F-Box Protein 31 | fbxo31 | 1.178 | 0.021 |
| Spliceosome Associated Factor 1, Recruiter Of U4/U6.U5 Tri-SnRNP | sart1 | 1.155 | 0.005 |
| Zinc Finger Protein 133 | znf133 | −1.127 | 0.006 |
| Zinc Finger Protein 551 | znf551 | −1.168 | 0.001 |
| Nibrin | nbn | −1.238 | 0.031 |
Genes were arranged according to six representative processes identified from the functional enrichment analysis. Gene description, respective acronym, fold-change intensity (FC), modulation (green: upregulation; red: downregulation), and p-value are described.