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. 2021 Mar 4;9:648024. doi: 10.3389/fcell.2021.648024

FIGURE 1.

FIGURE 1

Recognition of SBM-containing cargos and IncE by SNX5. (A) SNX-BARs are recruited to endosomes through coincident detection of SBM by the PX domain of SNX5/SNX6, and PtdIns(3)P by the PX domain of SNX1/SNX2. SNX-BARs mediates endocytic recycling of SBM-containing cargos, such as CI-MPR and SEMA4C, which is disrupted by Chlamydia effector IncE. (B) Sequence alignment between IncE and several SBM-containing cargos, with secondary structure listed above. Numbers in two sides indicate the primary sequences of respective proteins, whereas numbers on the top denote the corresponding order of designated residues in this review. Red colors represent residues involved in binding to SNX5. (C) Interaction between the CI-MPR peptide (yellow) with the PX domain of SNX5 (violet). Two different crystal structures between CI-MPR and SNX5 have been determined, with L21 (top) or M22 (bottom) from CI-MPR inserting in the same hydrophobic pocket on SNX5. (D) Interaction between the SEMA4C peptide (green) with the PX domain of SNX5 (violet). (E) Interaction between IncE (cyan) with the PX domain of SNX5 (violet).