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. 2021 Mar 10;6(10):3164–3176. doi: 10.1016/j.bioactmat.2021.02.023

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Cellular models of oxidative stress formulated by H₂O₂, LPS and high glucose. The effects of 300 μM H₂O₂, 1 μg/mL LPS and high glucose (22 mM) on intracellular production of ROS in MSCs (A, C, E) and Mϕs (B, D, F). Coculture of MSCs with conditioned medium (CM) from LPS-treated Mϕs indicated that macrophages amplified LPS-mediated upregulation of ROS in MSCs (C). Control: culture media without extra stimulation, LPS: LPS (1 μg/mL)-supplemented media, CM: conditioned media from LPS-treated Mϕs, LPS + CM: conditioned media from LPS-treated Mϕs mixed with extra LPS. *p < 0.05, **p < 0.01, ***p < 0.001. ns indicates no significant difference.