Fig. 8.

TNT mitigated compromised osteointegration of implants in diabetic-related oxidative stress rats. (A&B) Systematic oxidative stress levels, including urine 8-OHdG excretion and serum MDA levels, were measured in DM and normal rats. (C) Histological staining of hard tissue sections after implantation in the DM rat model for 4 and 8 weeks. The newly formed bone was stained red, while the fibrous tissues were stained blue, and implants were stained black. (D) Analysis of the percentages of bone-implant contact (BIC%) after 4 and 8 weeks of implantation. (E) The decrease rates of BIC%. *p < 0.05, **p < 0.01, ***p < 0.001. There was no significant difference between the two groups without *.