Table 1.

Effect of undenatured type II collagen (UC-II) supplementation on serum biochemical analyses in monosodium iodoacetate (MIA) induced osteoarthritis rats (n = 7).

Items	Groups			P*
	Control	MIA	MIA+UC-II
GLU (mg/dl)	108.00 ± 7.48	112.67 ± 11.33	108.67 ± 5.16	0.592
CR (mg/dl)	0.44 ± 0.09	0.41 ± 0.07	0.40 ± 0.09	0.768
BUN (mg/dl)	22.70 ± 2.32	23.52 ± 3.95	23.87 ± 3.49	0.825
TP (g/dl)	6.98 ± 0.18	6.73 ± 0.49	7.03 ± 0.20	0.260
ALP U/L	130.17 ± 12.7	103.67 ± 10.29*	131.67 ± 21.75#	0.012
GLOB (g/dl)	3.22 ± 0.19	3.28 ± 0.36	3.40 ± 0.14	0.456
ALT (U/L)	66.00 ± 5.87	70.50 ± 6.38	69.17 ± 5.71	0.430
AST (U/L)	111.33 ± 13.29	115.00 ± 8.17	111.83 ± 6.62	0.784
TBIL (mg/dl)	0.20 ± 0.01	0.20 ± 0.03	0.21 ± 0.02	0.504

MIA, monosodium iodoacetate; GLU, glucose; CR, creatinine; BUN, blood urea nitrogen; TP, total protein; GLOB, globulin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin. Mean values of parameters are demonstrated with ± standard deviations. ANOVA and Tukey's post hoc test were used to compare the results among different treatment groups. Statistical significance between groups is shown by

^*p < 0.05 compared to the control group and

^#p < 0.05 compared to the MIA group.