Table 3.
Sum of the mean fractional inhibitory concentration indices (ΣFICI) of the combinations between Ro48-8071 or tomatidine hydrochloride and benznidazole, posaconazole, or fexinidazole in different fixed ratio proportions (1:3, 1:1, and 3:1; the first number corresponds to the standard drug) against T. cruzi intracellular amastigotes (strain Tulahuen in L6 cell lines).
| Combos Mean ΣFICIs | Benznidazole | Posaconazole | Fexinidazole | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ro48-8071 | Tomatidine hydrochloride | Ro48-8071 | Tomatidine hydrochloride | Ro48-8071 | Tomatidine hydrochloride | |||||||
| EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | |
| 1:3 | 1.8 | 1.5 | 0.7 | 1.0 | 1.1 | 0.8 | 0.1 | 0.4 | 1.4 | 1.2 | 1.4 | 0.9 |
| 1:1 | 4.0 | 3.3 | 1.1 | 1.1 | 1.6 | 1.7 | 0.2 | 0.7 | 3.6 | 3.1 | 1.1 | 0.9 |
| 3:1 | 4.0 | 5.0 | 1.7 | 1.3 | 4.4 | 3.5 | 0.3 | 0.4 | 5.5 | 5.0 | 1.7 | 1.7 |
ΣFICI ≤ 0.5 synergism; 0.5 < ΣFICI ≤ 4 additive (no interaction); ΣFICI > 4 antagonism.