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. 2021 Feb 1;24(3):102131. doi: 10.1016/j.isci.2021.102131

Figure 6.

Figure 6

Associative memory in biological GRNs

(A and B) (A) Types of memory found in each of the 35 GRNs taken from the Cell Collective database. Associative memory was found in two of the GRNs: Aurora Kinase A in Neuroblastoma (B) and CD4+ T cell Differentiation and Plasticity (B). For each network, we present an example of the stimuli-response combination where AM is obtained. (A) Cell Collective network where 3 genes, WEE1, PP2A, and TPX2, act as UCS, R, and CS respectively. Activating TPX2 together with WEE1 enables TPX2 to activate PP2A, whereas previously only WEE1 did so.

(C) Cell Collective network where IL4e, IL4, and GATA3, respectively, act as UCS, R, and CS. Activating GATA3 together with IL4e enables GATA3 to activate IL4, whereas previously only gene IL4e did so.