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. 2021 Mar 4;12:619611. doi: 10.3389/fgene.2021.619611

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Copyright © 2021 Qian, Wei, Lu, Sun, Hwang, Jiang, Fu, Zhou, Kong, Zhu, Xiao, Hu and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The main regulatory network constructed based on prognosis-related IRGs and CRTFs. (A) The main regulatory network was constructed using Cytoscape for visualization. The circulars represent differentially expressed prognostic immune-related genes, and the purple triangles represent prognosis-related cancer-related transcription factors, respectively. The red circulars represent high-risk genes, and the green circulars represent low-risk genes. Red lines represent positive correlations and green lines represent negative correlations. (B) The PPI network was predicted using the Search Tool for the Retrieval of Interacting Genes online database. Analyzing the functional interactions between proteins may provide insights into the mechanisms of generation or development of CRC.