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Description of 27-gene IO algorithm gene profile.
| ‘Hot’ TME genes | CCL5, CD52, CXCL11, CXCL13, GZMB, IDO1, IL23A, ITM2A, KMO, KYNU, PSMB9, PTGDS, RARRES3, RTP4, S100A8, TNFAIP8, TNFSF10 |
| ‘Cold’ TME genes | APOD, ASPN, COL2A1, FOXC1, HTRA1, KRT16, MIA, SFRP1 |
| Uncertain | DUSP5, SPTLC2 |
