Table 6.
Univariate analysis of prognostic value of clinicopathological factors and MSI phenotype of DFS and OS of patients with stage III.
| Variable (DFS) | DFS | p | OS | p |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age at diagnosis | 0.991 | 0.511 | ||
| ≤49 | ||||
| >49 | ||||
| Menopause | 0.028 | 0.427 | ||
| Pre-menopausal | 1 | |||
| Post-menopausal | 2.284 (1.095–4.764) | |||
| Histological grade | 0.996 | 0.600 | ||
| I | ||||
| II | ||||
| III | ||||
| Tumor size | 0.295 | 0.693 | ||
| pT1 | ||||
| pT2 | ||||
| pT3 | ||||
| pT4 | ||||
| Nodal status | 0.003 | 0.155 | ||
| 1–3 nodes | 1 | |||
| 4–9 nodes | 1.3 (0.163–10.339) | |||
| ≥10 nodes | 4.808 (0.636–36.334) | |||
| Basal-like phenotype | 0.986 | 0.616 | ||
| Negative | ||||
| Positive | ||||
| Ki67 index* | 0.222 | 0.062 | ||
| ≤14 | 1 | |||
| >14 | 6.778 (0.909–50.526) | |||
| TIL | 0.277 | 0.330 | ||
| Low | ||||
| High | ||||
| Surgery | 0.100 | 0.059 | ||
| Breast-conserving | 1 | |||
| Radical mastectomy | 0.293 (0.082–1.045) | |||
| Chemotherapy | 0.432 | 0.143 | ||
| Negative | ||||
| Positive | ||||
| Radiotherapy | 0.037 | 0.009 | ||
| Negative | 1 | 1 | ||
| Positive | 0.435 (0.199–0.951) | 0.272 (0.102–0.721) | ||
| P53 | 0.726 | 0.525 | ||
| Negative | ||||
| Positive | ||||
| MSI | 0.073 | 0.671 | ||
| MSS | 1 | 1 | ||
| MSI-L | 2.894 (0.857–9.774) | 1.368 (0.319–5.865) |
MSI, microsatellite instability; DFS, Disease-free survival; OS, Overall survival; TNM, Primary Tumor/Regional Lymph Nodes/Distant Metastasis; TILs, tumor infiltrating lymphocytes; MSS, microsatellite stable; MSI-L, low-frequency microsatellite instability.
*Ki-67 index threshold of 14% was chosen according to the St. Gallen Consensus 2013.