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. 2021 Mar 16;12:20417314211000304. doi: 10.1177/20417314211000304

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Vascularization of implanted MVF-seeded CGAG matrices: (a, b) immunohistochemical detection of CD31⁺ microvessels (arrows) in MVF-seeded CGAG matrices on day 14 after implantation into full-thickness skin defects within the dorsal skinfold chamber of a vehicle- (a) and an EPO-treated (b) C57BL/6 mouse. Scale bars: 30 µm, (c) microvessel density (mm⁻²) of MVF-seeded matrices in vehicle- (control; white bar; n = 8) and EPO-treated (black bar; n = 8) C57BL/6 mice on day 14 after implantation, as assessed by immunohistochemical analysis. Means ± SEM, (d–f) immunohistochemical detection of CD31⁺/GFP⁺ microvessels (arrows) and CD31⁺/GFP⁻ microvessels (arrowheads) in a MVF-seeded CGAG matrix on day 14 after implantation into a full-thickness skin defect within the dorsal skinfold chamber of an EPO-treated C57BL/6 mouse. Scale bars: 30 µm, and (g) GFP⁺ microvessels (%) in MVF-seeded matrices of vehicle- (control; white bar; n = 8) and EPO-treated (black bar; n = 8) C57BL/6 mice on day 14 after implantation, as assessed by immunohistochemical analysis.

Means ± SEM.