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. 2021 Mar 15;11(3):e043221. doi: 10.1136/bmjopen-2020-043221

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Phases of participation in the Bugs and Brains Study. Participants eligible for the primary case–control component at phases 1 and 2 complete all phases of the study within a month, including biological sample collection (n=160; n=40 with IBS, n=40 with anxiety and/or depressive disorder, n=40 with IBS and anxiety and/or depressive disorder, n=40 controls with no lifetime history of either IBS or an anxiety/depressive disorder). Participants who decline sample collection, or are not eligible for the primary component, complete the questionnaire-only ancillary component (phases 1 and 4; n=1000). GAF, Global Assessment of Functioning; IBS, irritable bowel syndrome; SCID-5-RV, Structured Clinical Interview for the Diagnostic and Statistical Manual (DSM) fifth edition Research version; SOFAS, Social and Occupational Functioning Assessment Scale. Created with BioRender.com.