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. 2021 Mar 4;11:653614. doi: 10.3389/fonc.2021.653614

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Copyright © 2021 Wach, Apallas, Schneider, Güresir, Schuss, Herrlinger, Vatter and Güresir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Primary stratification tree that presents the cohorts prognoses. Each colored box represents the specified subgroup with the number of patients, median OS in months, and 95% confidence interval. The green boxes indicate the subgroups of patients with good survival prognosis, whereas the red boxes represent the patients with poor prognosis. The entire patient cohort was first divided into fibrinogen–CRP score (0) vs. fibrinogen–CRP score (≥1), which showed an increase of 3 months in overall survival among patients with an FC score of 0 compared to patients with an FC score ≥1. The hypermethylated MGMT promoter status is an independent predictor of prolonged survival in both groups. The additional stratification of patients with an FC score of 0 whose MGMT promoters were hypermethylated revealed that the GTR in these patients increased their OS to 44 months (95% CI: 23.1–64.9), whereas further stratification of the patients with an FC score ≥1 whose MGMT promoters were not hypermethylated revealed a median OS of 15 months (95% CI: 12.5–17.5).