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. 2021 Mar 4;12:601909. doi: 10.3389/fphar.2021.601909

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Copyright © 2021 Zhu, Xu, Deng, Yan, Li, Zhang and Chu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological changes in kidneys from the four groups of mice. (A) Control group. (B) Ang-(1–7) group. (C) LPS group. The microvilli of epithelial cells in renal tubules disappeared and part of the epithelium disintegrated. (D) LPS + Ang-(1–7) group. Red arrows indicate the pathological changes of renal tubular epithelial cells. Some mitochondria in epithelial cells of renal tubules swelled, and microvilli shedding and loss was noted. Pathological damage was less severe in the LPS + Ang-(1–7) group than that in the LPS group. Bars in A–D = 10 µm.