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. 2021 Mar 13;6(10):3300–3313. doi: 10.1016/j.bioactmat.2021.03.005

Fig. 6.

Fig. 6

Characterization of supramolecular hydrogel NapFFGEE-JSK/DOX and synergistic anticancer activity in vitro. (A) Optical images of NapFFGEE-JSK/DOX supramolecular hydrogel formed by mixing NapFFGEE-JSK (1 wt%) solution with DOX. (B) Zeta potentials of NapFFGEE-JSK/DOX nanofiber solution (0.1 wt%) diluted from NapFFGEE-JSK/DOX supramolecular hydrogel (1 wt%). (C) Rheological measurement in dynamic time sweep mode of JSK-NapFGEE/DOX (1 wt%) hydrogel and JSK-NapFGEE hydrogel. (D) In vitro pH sensitive DOX release from NapFFGEE-JSK/DOX hydrogel in PBS at different pH with GSH/GST. (E) In vitro cytotoxicity of NapFFGEE-JSK, DOX and NapFFGEE-JSK/DOX at 48 h. The JSK concentration was in range of 8–256 μM and DOX dose was various from 0.45 to 14.40 μg/mL. (F) Combination index (CI) values. (G) Cell apoptosis of MCF-7 ADR cells after treatment with PBS, NapFFGEE-JSK, DOX, NapFFGEE-JSK/DOX (62 μM).