Table 2. Correlates of Internal Work in the Community (FHS) and HFpEF (MGH-ExS)a.
| Covariate | Model (adjusted R2 = 0.25; n = 3037) | |||
|---|---|---|---|---|
| Estimated β | P value | |||
| FHS | ||||
| Age | 0.0085 | .65 | ||
| Female | –0.43 | <.001 | ||
| BMI, log | 0.48 | <.001 | ||
| Diabetes | 0.076 | .23 | ||
| Hypertension | –0.014 | .71 | ||
| CVD | –0.096 | .23 | ||
| Resting SBP, log | 0.019 | .39 | ||
| Resting DBP, log | –0.073 | <.001 | ||
| Resting HR, log | 0.0073 | .67 | ||
| Peak V̇o2, log, mL/min | –0.29 | <.001 | ||
| Covariate | Model 1 (adjusted R2 = 0.31; n = 183) | Model 2 (adjusted R2 = 0.33; n = 173) | ||
| Estimated β | P value | Estimated β | P value | |
| HFpEF (MGH-ExS) | ||||
| Age | –0.096 | .22 | –0.073 | .39 |
| Female | –0.17 | .28 | –0.082 | .63 |
| BMI, log | 0.67 | <.001 | 0.70 | <.001 |
| Diabetes | 0.22 | .12 | 0.294 | .05 |
| Hypertension | 0.060 | .69 | 0.066 | .67 |
| Resting SBP, log | 0.127 | .15 | 0.108 | .26 |
| Resting DBP, log | –0.174 | .05 | –0.147 | .13 |
| Resting HR, log | 0.036 | .61 | 0.038 | .61 |
| Peak V̇o2, log, mL/min | –0.411 | <.001 | –0.36 | .002 |
| Resting PCWP, log | NA | NA | 0.16 | .11 |
| Resting RA pressure | NA | NA | –0.128 | .19 |
| Resting CO, log | NA | NA | –0.023 | .80 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CO, cardiac output; CVD, cardiovascular disease; DBP, diastolic blood pressure; FHS, Framingham Heart Study; HFpEF, heart failure with preserved ejection fraction; HR, heart rate; MGH-ExS, Massachusetts General Hospital Exercise Study; NA, not applicable; PCWP, pulmonary capillary wedge pressure; RA, right atrial pressure; SBP, systolic blood pressure; V̇o2, oxygen uptake.
a
Continuous variables were standardized. Values were log transformed where specified. RA was not log transformed because of some negative values.