Fig. 2.

Forest plot of the 28-day mortality risk ratios between intervention and control arms.

Meta-analysis of the relative risk of mortality between intervention and control arms of included studies, expressed as risk ratios with 95% confidence intervals (CI), depicted graphically as a forest plot. The majority of studies reported mortality at 28 days; RCT-TCZ-COVID-19 reported at day 30, TOCIBRAS and Lescure et al. at day 29, and REMAP-CAP at day 21. The relative weighting of each study from a random effects model is shown. For studies comparing two interventions (either different doses or different IL-6 inhibitors), the intervention arms are included separately, whilst the number of patients contributing to the control arms were divided equally for use as a comparator. Heterogeneity between studies was assessed using I² statistics. TCZ: Tocilizumab; SARI: Sarilumab.