Fig. 4.
A: Eigengene correlation network between the Addenbrooke's Cognitive Examination (ACE-III) cognitive traits at baseline and microbiome modules (MM1-MM8) within the PL condition. B: Consensus correlation network between oral microbiome modules and 32 cognitive and physiological traits. Only three significant consensus module-trait relationships persisted across placebo and nitrate conditions: MM5 correlated with reaction time in the ‘information processing’ cognitive function test, MM6 correlated with MAP, and MM7 correlated with pulmonary O2 uptake at rest. The colour scale on the right-hand side of each panel indicates the strength of positive (green) and inverse (red) correlations. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)