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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: Int J Pharm. 2020 Oct 26;591:119989. doi: 10.1016/j.ijpharm.2020.119989

Table 1 -.

siRNA deposition onto LbL nanosystems

5 mg of
MSN_IR-780		 siRNA
(initial
amount)		 Encapsulation
efficiency - total
siRNA		 Percentage of
AF 488 siRNA
in total siRNA		 Percentage of
AF 488 siRNA
in LbL
nanoparticles
After siRNA layering ≈ 2040 μg (120 nmol of siRNA Kras or NC + 16 nmol of AF 488 siRNA) 11.4 % = 232.2 μg 1.2 % of initial siRNA = 25.1 μg 10.8%
After enzymes degradation 10.7 % = 219.1 μg 1.1 % of initial siRNA = 23.3 μg 10.6%