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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: Math Med Biol. 2018 Dec 5;35(4):493–516. doi: 10.1093/imammb/dqx018

Fig. 1.

Fig. 1.

(a, b) Snapshots of an embryonic zebrafish’s ventricle at 96 hpf right using spinning disk confocal microscopy. The snapshots were taken right before its diastolic and systolic phase, respectively. The protrusions into the ventricular chamber are trabeculae. Dashed lines show the minor and major axes. Images are from Tg(cmlc2:dsRed)s879; Tg(flk1:mcherry)s843 embryos expressing fluorescent proteins that label the myocardium and endocardium, respectively (Liu et al., 2010). The red fluoresces the myocardium, while the green fluoresces the endocardium. (c, d) illustrate the computational geometry right before diastole and systole, respectively. The computational geometry, as shown in (e), includes the two chambers, the atrium (bottom chamber) and ventricle (top chamber), the atrioventricular canal connecting the chambers and the bulbus arteriosus and sinus venosus, which all have endocardial cushions, which can occlude cardiac flow, as well as flexible blood cells.