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. 2021 Mar 2;6(10):7165–7174. doi: 10.1021/acsomega.1c00241

Figure 2.

Figure 2

EDTs restore the viability of HEK293 cells exposed to tunicamycin (Tun). (A) Pretreatment with EDTs (methyl esters, regioisomeric mixture, 1 μM) or EETs significantly improved cell viability following prolonged (24 h) exposure to 4 μg/mL Tun (one-way analysis of variance, Holm–Sidak method, *p < 0.001 vs dimethyl sulfoxide (DMSO) + Tun group, α = 0.05). (B) Dose response of the protective action of EDTs, with maximal therapeutic activity occurring at a 1 μM dose of EDT methyl esters (regioisomer mixture).