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. 2021 Jan 20;11:611794. doi: 10.3389/fphar.2020.611794

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Copyright © 2021 Ding, Zhu, Diao, Xu, Wang, Qu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginseng treatment attenuates LPS-induced acute lung injury in mice. Mice were administered (p.o.) ginseng (Gin, 0.1, 0.5, and 1 g/kg) or prednisone (PDN, 7 mg/kg, positive drug) once a day for 1 week before intratracheal instillation of LPS (A) Weight loss, (B) pulmonary index, and (C) WW:DW ratio of the lung are displayed in histograms; (D) representative H&E-stained section of lung tissue (blue arrow shows inflammatory cell infiltration or alveolar wall thickening). Data are the mean ± SD (n = 7). ##p < 0.01 and ###p < 0.001 vs. the control group; *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the LPS group.