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. 2021 Jan 20;11:611794. doi: 10.3389/fphar.2020.611794

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Copyright © 2021 Ding, Zhu, Diao, Xu, Wang, Qu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginseng treatment reduced the number of inflammatory cells and expression of proinflammatory cytokines in BALF. Mice were administered (p.o.) ginseng (Gin, 0.1, 0.5, and 1 g/kg) or prednisone (PDN, 7 mg/kg, positive drug) once a day for 1 week before intratracheal instillation of LPS (A–C) The number of total cells, neutrophils, and macrophages in BALF was determined by counting microscopic fields after staining with Wright–Giemsa solution. (D–F) Expressions of IL-1β, IL-6, and TNF-α in BALF were measured by ELISA. Data are the mean ± SD (n = 3). ^## p < 0.01 and ^### p < 0.001 vs. the control group; *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the LPS group.