Table 3.
Drug and nutritional data in the first week of life
| CGM group (n=80) | Standard care group (n=94) | Adjusted mean difference (95% CI) | p value | |
|---|---|---|---|---|
| Medication received | ||||
| Inotropes | 19 (24%) | 27 (29%) | .. | .. |
| Antibiotics | 75 (94%) | 90 (96%) | .. | .. |
| Caffeine | 80 (100%) | 94 (100%) | .. | .. |
| Morphine | 32 (40%) | 40 (43%) | .. | .. |
| Corticosteroids | 3 (4%) | 6 (6%) | .. | .. |
| Insulin | 49 (61%) | 35 (37%) | .. | .. |
| Nutritional intake | ||||
| Daily intravenous glucose, g/kg* | 9·9 (2·6) | 9·2 (2·4) | 0·69 (0·02 to 1·35) | 0·043 |
| Daily intravenous amino acids, g/kg* | 2·2 (1·2) | 2·2 (1·3) | 0·17 (−0·06 to 0·40) | 0·58 |
| Daily intravenous lipids, g/kg* | 1·89 (0·77) | 1·95 (0·78) | −0·04 (−0·21 to 0·13) | 0·64 |
| Daily oral nutrition, mL/kg*† | 20 (21) | 18 (23) | 2·0 (−3·6 to 7·6) | 0·49 |
| Daily intravenous fluids, mL/kg* | 118 (23) | 113 (24) | NA | NA |
| Total insulin, units per kg per day* | 0·60 (0·94) | 0·57 (2·14) | 0·08 (−3·3 to 3·5) | 0·96 |
Data are n (%) or mean (SD), unless indicated otherwise. Mean differences were adjusted for gestational age and centre. CGM=continuous glucose monitoring. NA=not available: daily intravenous fluids were assessed post hoc and no statistical comparison was done.
Data available for: daily glucose n=84 in the standard care group, n=81 in the GCM group; daily amino acids n=94 in the standard care group, n=81 in the CGM group; daily lipids n=92 in the standard care group, n=80 in the CGM group; daily oral nutrition n=94 in the standard care group, n=81 in the CGM group; daily intravenous fluids n=94 in the standard care group, n=81 in the CGM group; total insulin n=94 in the standard care group, n=80 in the CGM group.
Oral nutrition included expressed maternal milk, donor milk, or preterm formula, dependent on availability and maternal preference.