Table 1.

Protocol of rituximab dosing and administration.

Substance	Administration route	Dosage
Rituximab	i.v.	1000 mg at 0 days, 500 mg every 6 months (Patients initiating treatment between 01.01.2015 and 31.12.2016: 1000 mg at 0 days, 1000 mg at 14 days, 500 mg every 6 months.)
Paracetamol	p.o.	Premedication with an antipyretic (paracetamol 1000 mg tablet) approximately 30-60 minutes prior to each infusion.
Cetirizine	p.o.	Premedication with an antihistamine (cetirizine 10 mg tablet) approximately 30-60 minutes prior to each infusion;
Methylprednisolone	i.v.	Premedication with 125 mg intravenous methylprednisolone approximately 30 minutes prior to each infusion
In case of infusion reactions:
Cetirizine	p.o.	Cetirizine 10 mg tablet