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. Author manuscript; available in PMC: 2021 Oct 27.
Published in final edited form as: ACS Nano. 2020 Sep 25;14(10):12732–12748. doi: 10.1021/acsnano.0c03064

Figure 5: Design and synthesis of keratinocyte-targeted lipid nanoparticles (TLNPκ) to inhibit miRNA packaging within exosome.

Figure 5:

(A) Schematic representation of the keratinocyte-targeted lipid nanoparticles TLNPκ. (B) Mass spectrometric analysis of DSPE-PEG2000-A5G33 and DSPE-PEG-NHS using MALDI-TOF. (C) Zeta potentials of TLNPκ at different pH. (D) Gel retardation assay of TLNPκ showing encapsulation efficiency of TLNPκ. (E) Representative Transmission Electron Microscopy (TEM) image of TLNPκ. Scale, 500 nm. (F) Representative nanoparticle tracking analysis (NanoSight) showing particle size distribution and concentration of non-TLNPκ and TLNPκ.