Table I.
Clinical characteristics of the patients with intrauterine adhesions in the test cohort and validation cohort.
| Test cohort |
Validation cohort |
|||||||
|---|---|---|---|---|---|---|---|---|
| Clinical characteristic | Category | Live birth group | No live birth group | P1 | Live birth group | No live birth group | P2 | Total |
| Age | N (N missing) | 231 (0) | 226 (0) | P = 0.0003 | 117 (0) | 168 (0) | P = 0.0061 | 742 (0) |
| Mean (SD) | 30.3 (4.30) | 31.9 (4.94) | 30.5 (4.48) | 32.1 (4.84) | 31.2 (4.71) | |||
| Gravidity | 1 | 47 (20.3%) | 53 (23.5%) | P = 0.0038 | 28 (23.9%) | 40 (23.8%) | P = 0.4333 | 168 (22.6%) |
| 2 | 73 (31.6%) | 41 (18.1%) | 39 (33.3%) | 45 (26.8%) | 198 (26.7%) | |||
| ≥3 | 111 (48.1%) | 132 (58.4%) | 50 (42.7%) | 83 (49.4%) | 376 (50.7%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Parity | 1 | 228 (98.7%) | 218 (96.5%) | P = 0.1390 | 113 (96.6%) | 161 (95.8%) | P = 0.8744 | 720 (97.0%) |
| 2 | 2 (0.9%) | 7 (3.1%) | 3 (2.6%) | 6 (3.6%) | 18 (2.4%) | |||
| ≥3 | 1 (0.4%) | 1 (0.4%) | 1 (0.9%) | 1 (0.6%) | 4 (0.5%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Abortion | 1 | 75 (32.5%) | 75 (33.2%) | P = 0.0692 | 48 (41.0%) | 62 (36.9%) | P = 0.7866 | 260 (35.0%) |
| 2 | 75 (32.5%) | 53 (23.5%) | 34 (29.1%) | 52 (31.0%) | 214 (28.8%) | |||
| ≥3 | 81 (35.1%) | 98 (43.4%) | 35 (29.9%) | 54 (32.1%) | 268 (36.1%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Recurrent IUA | Yes | 42 (18.2%) | 75 (33.2%) | P = 0.0003 | 27 (23.1%) | 56 (33.3%) | P = 0.0648 | 200 (27.0%) |
| No | 189 (81.8%) | 151 (66.8%) | 90 (76.9%) | 112 (66.7%) | 542 (73.0%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Menstruation | NA | 1 (0.4%) | 1 (0.4%) | P = 0.0168 | 0 (0.0%) | 0 (0.0%) | P = 0.0445 | 2 (0.3%) |
| Eumenorrhea | 29 (12.6%) | 26 (11.5%) | 3 (2.6%) | 0 (0.0%) | 58 (7.8%) | |||
| Oligomenorrhea | 189 (81.8%) | 170 (75.2%) | 110 (94.0%) | 156 (92.9%) | 625 (84.2%) | |||
| Amenorrhea | 12 (5.2%) | 29 (12.8%) | 4 (3.4%) | 12 (7.1%) | 57 (7.7%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| IUA course | NA | 36 (15.6%) | 43 (19.0%) | P = 1.0000 | 0 (0.0%) | 0 (0.0%) | P = 1.0000 | 79 (10.6%) |
| ≤6 months | 52 (22.5%) | 49 (21.7%) | 46 (39.3%) | 65 (38.7%) | 212 (28.6%) | |||
| >6 months | 143 (61.9%) | 134 (59.3%) | 71 (60.7%) | 103 (61.3%) | 451 (60.8%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Uterine cavity length | N (N miss) | 227 (4) | 221 (5) | P = 0.0114 | 117 (0) | 168 (0) | P = 0.1502 | 733 (9) |
| Mean (SD) | 7.2 (0.52) | 7.0 (0.68) | 7.3 (0.61) | 7.2 (0.74) | 7.1 (0.64) | |||
| Uterine horn adhesion | Bilateral adhesion | 4 (1.7%) | 10 (4.4%) | P = 0.0869 | 4 (3.4%) | 18 (10.7%) | P = 0.0446 | 36 (4.9%) |
| Unilateral adhesion | 2 (0.9%) | 6 (2.7%) | 2 (1.7%) | 6 (3.6%) | 16 (2.2%) | |||
| None adhesion | 225 (97.4%) | 210 (92.9%) | 111 (94.9%) | 144 (85.7%) | 690 (93.0%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| Visibility of fallopian tube ostia | Bilateral invisible | 5 (2.2%) | 22 (9.7%) | P = 0.0000 | 7 (6.0%) | 24 (14.3%) | P = 0.0104 | 58 (7.8%) |
| Unilateral invisible | 5 (2.2%) | 23 (10.2%) | 5 (4.3%) | 17 (10.1%) | 50 (6.7%) | |||
| Bilateral visible | 221 (95.7%) | 181 (80.1%) | 105 (89.7%) | 127 (75.6%) | 634 (85.4%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| DEGO degree | NA | 1 (0.4%) | 14 (6.2%) | P = 0.0000 | 0 (0.0%) | 0 (0.0%) | P = 0.0000 | 15 (2.0%) |
| G0 | 39 (16.9%) | 3 (1.3%) | 24 (20.5%) | 3 (1.8%) | 69 (9.3%) | |||
| G1 | 152 (65.8%) | 56 (24.8%) | 70 (59.8%) | 38 (22.6%) | 316 (42.6%) | |||
| G2 | 35 (15.2%) | 109 (48.2%) | 19 (16.2%) | 86 (51.2%) | 249 (33.6%) | |||
| G3 | 4 (1.7%) | 44 (19.5%) | 4 (3.4%) | 41 (24.4%) | 93 (12.5%) | |||
| Total | 231 (100.0%) | 226 (100.0%) | 117 (100.0%) | 168 (100.0%) | 742 (100.0%) | |||
| AFS score | N (N miss) | 230 (1) | 226 (0) | P = 0.0000 | 117 (0) | 168 (0) | P = 0.0000 | 741 (1) |
| Mean (SD) | 2.7 (1.01) | 3.5 (2.03) | 2.8 (1.52) | 3.8 (2.28) | 3.2 (1.83) | |||
IUA, Intrauterine adhesion; AFS, American Fertility Society; DEGO, the density of endometrial glandular openings; P1, P-value for Test cohort; P2, P-value for Validation cohort; NA, no answer; G1, grade 1 of DEGO; G2, grade 2 of DEGO; G3, grade 3 of DEGO.