Table 3.

Peak intratidal NO concentrations during “pulsed delivery” with 40 ppm target

	40 cm distal to ventilator	120 cm distal to ventilator	Y-piece	Trachea	Artificial lung
OBC	184.73	133.03	103.33	107.5	33.68
ECS	n/d	n/d	28.3	n/d	n/d

In “pulsed delivery” mode with a target of 40 ppm, a bolus of NO was injected at the beginning of inspiration into the breathing circuit at 20 cm after the mechanical ventilator, sampled from the indicated sites along the breathing circuit, and quantified with ozone-based chemiluminescence (OBC). Mechanical ventilation was performed with 750 ml of tidal volume via volume-controlled ventilation with I:E ratio of 1:1. (1 condition). Peak intratidal NO concentrations were determined over a period of 120 s (n = 30 respiratory cycles) at each sampling site. Gas samples form the y-piece also underwent quantification with the built-in electrochemical sensor (ECS at 4 cm proximal of the y-piece) of the NO administration device

n/d not determined