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. 2021 Feb 25;11:569295. doi: 10.3389/fonc.2021.569295

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Copyright © 2021 Liang, Wan, Zhu, Wang, Jiang, Huang, Luo, Chen, Yang, Li and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comprehensive regulatory network for resveratrol in treating MDA-MB-231 cells. (A) (a) POLD1 expression in BRCA samples of TCGA database. (b) POLD1 expression in MDA-MB-231 cells samples after resveratrol treatment. (B) Protein expression of POLD1 after treatment with different concentrations of resveratrol (*P=0.043, **P=0.004, ***P<0.001). (C) Combined prediction model of resveratrol and POLD1 domain. (D) POLD1-differential apoptotic pathway gene-apoptotic pathway correlation pathway map. (E) Comprehensive regulatory network diagram. Red represents POLD1, yellow represents genes that interact with POLD1, blue represents genes that are affected by other resveratrol treatments for TNBC, and green represents pathways.