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. 2021 Mar 4;12:603649. doi: 10.3389/fimmu.2021.603649

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Copyright © 2021 Mountford, Effenberger, Noll-Puchta, Griessmair, Ringleb, Haas, Denk, Reiter, Mayr, Dinarello, Tilg and Bufler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transgene IL-37 expression is associated with improved survival, liver function tests, and reduced liver fibrogenesis after BDL. Wt and IL-37tg mice underwent BDL or sham operation. (A) Survival curve. (B) Liver function tests. (C) ECM deposition in liver sections as assessed and quantified by Sirius red staining. (D) Hepatic mRNA was quantified by qPCR 3 days after BDL. Fold changes of mRNA expression were calculated using the ΔΔCt-method normalized to Rpl13a gene expression. Open circles: Wt-sham (n = 5), Open boxes: Wt (n = 5), Closed boxes: IL-37tg (n = 6). *p < 0.05, **p < 0.01.