Table 1.
NCD |
HFD |
|||
---|---|---|---|---|
SPT flox (n = 6) | aSPTLC2 KO (n = 6) | SPT flox (n = 5) | aSPTLC2 KO (n = 6) | |
Body weight (g) | 24.1 ± 0.2 | 25.6 ± 0.5* | 26.2 ± 0.6# | 26.2 ± 0.5 |
Plasma glucose (mg/dL) | 100.6 ± 2.7 | 152.7 ± 7.3* | 95.8 ± 9.5 | 145.6 ± 11.8* |
ALT (units/L) | 38.8 ± 10.2 | 19.3 ± 7.4 | 33.9 ± 7.7 | 92.3 ± 26.8* |
AST (units/L) | 156.1 ± 52.1 | 141.9 ± 32.4 | 135.3 ± 31.4 | 206 ± 57.9 |
T-CHO (mg/dL) | 95.8 ± 4.3 | 117.3 ± 4.4* | 170.7 ± 18.9 | 156.1 ± 28.5 |
TG (mg/dL) | 117.8 ± 11.2 | 115.7 ± 13.6 | 86.4 ± 9.5 | 88.2 ± 18.4 |
HDL (mg/dL) | 64.6 ± 3.2 | 81.4 ± 2.9* | 113.7 ± 12.8 | 103.6 ± 15.4 |
LDL (mg/dL) | 12.1 ± 0.8 | 12.3 ± 0.8 | 23.5 ± 3.6 | 20.5 ± 5.7 |
NEFA (mEq/L) | 12.8 ± 0.5 | 9.8 ± 1.0* | 10.5 ± 1.3 | 9.5 ± 0.3* |
β-OH butyrate (μmol/L) | 100.6 ± 19 | 188.3 ± 32* | 102.5 ± 28 | 137.5 ± 10 |
Data are means ± SEM. ALT, alanine transaminase; AST, aspartate aminotransferase; β-OH, β-hydroxybutyrate; NEFA, nonesterified FA; T-CHO, total cholesterol.
*P < 0.05 vs. SPT flox;
#P < 0.05 vs. SPT flox fed an NCD.