Table 1.

Plasma parameters of the floxed and aSPTLC2 KO mice fed an NCD or the 45% HFD for 8 weeks

	NCD		HFD
	SPT flox (n = 6)	aSPTLC2 KO (n = 6)	SPT flox (n = 5)	aSPTLC2 KO (n = 6)
Body weight (g)	24.1 ± 0.2	25.6 ± 0.5*	26.2 ± 0.6#	26.2 ± 0.5
Plasma glucose (mg/dL)	100.6 ± 2.7	152.7 ± 7.3*	95.8 ± 9.5	145.6 ± 11.8*
ALT (units/L)	38.8 ± 10.2	19.3 ± 7.4	33.9 ± 7.7	92.3 ± 26.8*
AST (units/L)	156.1 ± 52.1	141.9 ± 32.4	135.3 ± 31.4	206 ± 57.9
T-CHO (mg/dL)	95.8 ± 4.3	117.3 ± 4.4*	170.7 ± 18.9	156.1 ± 28.5
TG (mg/dL)	117.8 ± 11.2	115.7 ± 13.6	86.4 ± 9.5	88.2 ± 18.4
HDL (mg/dL)	64.6 ± 3.2	81.4 ± 2.9*	113.7 ± 12.8	103.6 ± 15.4
LDL (mg/dL)	12.1 ± 0.8	12.3 ± 0.8	23.5 ± 3.6	20.5 ± 5.7
NEFA (mEq/L)	12.8 ± 0.5	9.8 ± 1.0*	10.5 ± 1.3	9.5 ± 0.3*
β-OH butyrate (μmol/L)	100.6 ± 19	188.3 ± 32*	102.5 ± 28	137.5 ± 10

Data are means ± SEM. ALT, alanine transaminase; AST, aspartate aminotransferase; β-OH, β-hydroxybutyrate; NEFA, nonesterified FA; T-CHO, total cholesterol.

*P < 0.05 vs. SPT flox;

#P < 0.05 vs. SPT flox fed an NCD.