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. 2021 Mar 10;11:5589. doi: 10.1038/s41598-021-84984-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between lifetime telomere length dynamics and productive lifespan. RLTL measurements were grouped into tertiles as shown for (a) mean RLTL, (b) mean absolute RLTL change and (c) mean RLTL change. Kaplan–Meier curves show relationship of lifetime RLTL dynamics tertiles with productive lifespan. (d) Greater lifetime mean RLTL (tertile 3) was not significantly differently associated with productive lifespan than moderate or short lifetime mean RLTL (tertiles 2 and 1). (e) Greater mean absolute RLTL change (tertile 3) measured over the lifetime was associated with shorter productive lifespan compared to animals with moderate (tertile 2) or little (tertile 1) mean absolute RLTL change. (f) Greater mean lifetime RLTL attrition was associated with shorter productive lifespan. It can be seen that the mean survival of the group with the most RLTL attrition was about 600 days shorter than the mean survival of the group showing the most stable RLTL with neither dramatic shortening nor elongation (tertile 2).