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. 2021 Mar 11;11:5748. doi: 10.1038/s41598-021-85061-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Modifiers of C9orf72 and FUS toxicity converge on top hubs of ribosomal-associated module SC.M6. (A) Enrichment of genetic modifiers of C9orf72 and FUS toxicity^26–28 within co-expression modules. Odds ratios of enrichments with FDR corrected p-value < 0.05 are shown. FDR corrected p-values themselves are shown within parentheses. (B) Indirect protein–protein interaction (PPI) network of the top 100 hub genes from module SC.M6. Gene vertices are color coded as shown. P-value of the PPI network is derived from 1000 permutations.