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. 2021 Mar 11;11:5804. doi: 10.1038/s41598-021-83930-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Day-21 safety analysis of the vaccine candidates, SK-01 V1, and OZG-3861 V1. Histopathologic analysis on day 21 of (A) lung (the arrow; chronic inflammation X100), jejunum of the intestine, liver, spleen, and (B) cerebellum of brain, hippocampus, kidney, and skin. In the spleen, stars show foci of megakaryocytes and arrows were trabeculae (X400 H + E stain). In the cerebellum, the thin arrow shows dendrites, the thick arrow shows picnotic cell, the thin double-headed arrow shows space. In the hippocampus, P is the pyramidal cell layer and D is the dentate gyrus (X100 H + E stain). In the kidney, the arrow shows interstitial chronic inflammation (X400 H + E stain). In the skin, black arrows show infiltrated inflammatory cells and red arrows show eosinophils (X40 H + E stain). (C) Bar graphs showing quantitated mouse cytokine bead array analysis by assessing Th1, Th2, and Th17 specific cytokines (picogram/ml) in mice serum collected on day 21 of the vaccine treatment.

Day-21 safety analysis of the vaccine candidates, SK-01 V1, and OZG-3861 V1. Histopathologic analysis on day 21 of (A) lung (the arrow; chronic inflammation X100), jejunum of the intestine, liver, spleen, and (B) cerebellum of brain, hippocampus, kidney, and skin. In the spleen, stars show foci of megakaryocytes and arrows were trabeculae (X400 H + E stain). In the cerebellum, the thin arrow shows dendrites, the thick arrow shows picnotic cell, the thin double-headed arrow shows space. In the hippocampus, P is the pyramidal cell layer and D is the dentate gyrus (X100 H + E stain). In the kidney, the arrow shows interstitial chronic inflammation (X400 H + E stain). In the skin, black arrows show infiltrated inflammatory cells and red arrows show eosinophils (X40 H + E stain). (C) Bar graphs showing quantitated mouse cytokine bead array analysis by assessing Th1, Th2, and Th17 specific cytokines (picogram/ml) in mice serum collected on day 21 of the vaccine treatment.