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. 2021 Mar 11;11:5804. doi: 10.1038/s41598-021-83930-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pre-clinical efficacy study of vaccine candidates, SK-01 V1, and OZG-3861 V1. (A) Bar graph showing SARS-CoV-2 specific IgG analysis of the groups concerning the positive control antibody, mouse SARS-CoV-2 Spike S1 monoclonal antibody using ELISA. (B) Upper graph showing RTCA analysis of infective active SARS-CoV-2 in a dose-dependent manner for 6 days. Bar graph showing quantified normalized cell index values of SARS-CoV-2 titrations to determine TCID50 dose. (C) Representative RTCA graph of neutralization assay in which 1:128 and 1:256 dilutions of adjuvant positive double-dose (SK-01 V1) and control mice serum preincubated with 100 × TCID50 dose of SARS-CoV-2. (D) Bar graph showing quantified virus neutralization ratio of the vaccine treated groups at 1:128 and 1:256 dilutions. (E) Bar graph showing quantitated SARS-CoV-2 copy numbers when culturing on healthy adult monocytes along with 1:256 mice serum to determine Antibody-Dependent Enhancement (ADE). The threshold of significance for all tests was set at *p < 0.05. NS is Non-Significant.