Table 1.
Identified variants in four patients.
| Nucleotide position | Gene/region | Gene product | Nucleotide exchange (Ref/Alt) | Amino acid exchange | Mutation type | Conservation among 9332 samples (%) | Frequency in this study (%) | Detection in previous studies |
|---|---|---|---|---|---|---|---|---|
| 22,227 | S | Surface glycoprotein | C/T | A222V | Missense | 99.09 | 15.4 | Novel |
| 241 | 5′ UTR | Non-coding | C/T | – | Non-coding | 59.52 | 53.8 | Detected |
| 2113 | ORF1ab | Nsp2 | C/T | I436I | Synonymous | 98.07 | 61.5 | Detected |
| 3037 | ORF1ab | Nsp3 | C/T | F106F | Synonymous | 61.27 | 30.8 | Detected |
| 7765 | ORF1ab | Nsp3 | C/T | S1682S | Synonymous | 98.18 | 15.4 | Detected |
| 14,408 | ORF1ab | RNA-dependent RNA Polymerase | C/T | P323L | Missense | 61.01 | 23.1 | Detected |
| 17,523 | ORF1ab | Helicase | G/T | M429I | Missense | 98.50 | 23.1 | Detected |
| 17,690 | ORF1ab | Helicase | C/T | S485L | Missense | 98.02 | 61.5 | Detected |
| 18,877 | ORF1ab | 3′-to-5′ exonuclease | C/T | L280L | Synonymous | 96.13 | 30.8 | Detected |
| 23,403 | S | Surface glycoprotein | A/G | D614G | Missense | 61.39 | 15.4 | Detected |
| 25,563 | ORF3a | ORF3a protein | G/T | Q57H | Missense | 71.27 | 53.8 | Detected |