Table 1.
Gene ID, definition, Kegg pathway, GO-molecular function and GO-biological process found in Podarcis or Anolis annotated genomes of the 1,355 outliers SNPs obtained by BayeScan analysis and the posterior filters. References of studies related with specific biological functions are included.
| Gene | Definition | Kegg pathway | GO-molecular function | GO-biological process | References |
|---|---|---|---|---|---|
| ACACB | Acetyl-CoA carboxylase 2 | Fatty acid biosynthesis, pyruvate metabolism, propanoate metabolism, metabolic pathways, insulin signalling pathway, adipocytokine signalling pathway | Acetyl-CoA carboxylase activity, ATP binding, identical protein binding, metal ion binding | Acetyl-CoA metabolic process, fatty acid biosynthesis process, malonyl-CoA biosynthetic process, protein homotetramerization | Lipid metabolism, hibernation69 |
| ACSBG1 | Acyl-CoA synthetase bubblegum family member 1 | Fatty acid biosynthesis, fatty acid degradation, metabolic pathways, fatty acid metabolism, PPAR signalling pathway, adipocytokine signalling pathway | CoA-ligase activity, long-chain fatty acid-CoA ligase activity, very long-chain fatty acid-CoA ligase activity | Long-chain fatty acid biosynthesis process, response to glucocorticoid, very long-chain fatty acid metabolic process | Lipid metabolism, hibernation70 |
| ADAM2 | ADAM metallopeptidase domain 2 |
Disintegrins and metallopeptidase activity, metal ion binding, metalloendopeptidase activity, toxin activity |
Integrin-mediated signalling pathway | Fertility71 | |
| ADAM9 | ADAM metallopeptidase domain 9 |
Disintegrins and metallopeptidase activity, collagen binding, metal ion binding, toxin activity Collagen, integrin, laminin. Metal ion and SH3 domain binding, metalloendopeptidase activity, toxin activity |
Activation of MAPKK activity, cell–cell adhesion mediated by integrin, cell–matrix adhesion, cellular response to lipopolysaccharide, keratinocyte differentiation, membrane protein ectodomain proteolysis, monocyte activation, positive regulation of cell adhesion mediated by integrin, keratinocyte migration, macrophage fusion and protein secretion, response to calcium ion, hydrogen peroxide, manganese ion, tumor necrosis factor, transforming growth factor beta receptor signalling pathway | Fertility, tail regeneration71,72 | |
| ADAMTS17 | ADAM metallopeptidase with thrombospondin type 1 motif 17 | Metal ion binding and metallopeptidase activity | Extracellular matrix organization | 73 | |
| ADCY1 | Adenylate cyclase 1 | Purine metabolism, metabolic pathways, calcium signalling pathway, oocyte meiosis, adrenergic signalling in cardiomyocytes, vascular smooth muscle contraction, apelin signalling pathway, gap junction, GnRH signalling pathway, progesterone-mediated oocyte maturation, melanogenesis | Adenylate cyclase activity, ATP binding, metal ion binding | Adenylate cyclase-activating G protein-coupled receptor signalling pathway, axonogenesis, cAMP biosynthetic process, long-term memory, neuroinflammatory response, positive regulation of CREB transcription factor activity and long-term synaptic potentiation, reulation of circadian rhythm and synaptic vesicle exocytosis | Circadian rhythm74 |
| ADCY2 | Adenylate cyclase 2 | Purine metabolism, metabolic pathways, calcium signalling pathway, oocyte meiosis, adrenergic signalling in cardiomyocytes, vascular smooth muscle contraction, apelin signalling pathway, gap junction, GnRH signalling pathway, progesterone-mediated oocyte maturation, melanogenesis | Adenlylate cyclase activity, ATP binding, metal ion binding | Adenylate cyclase-activating G protein-coupled receptor signalling pathway, axonogenesis, cAMP biosynthetic process | 73 |
| ANK1 | Ankyrin 1 | ATPase binding, cytoskeletal anchor activity, ion channel binding, protein phosphatase binding, spectrin binding | Endoplasmic reticulum to Golgi vesicle-mediated transport, protein localization to plasma membrane | Transcriptional factors, cell regulators, cytoskeletal, ion transporters and signal transducers75 | |
| ANKRD13A | Ankyrin repeat domain 13A | ||||
| CACNA1G | Calcium voltage-gated channel subunit alpha1 G | MAPK and calcium signalling pathway | Voltage-gated calcium and sodium channel activity, scaffold protein binding, cation channel activity | Calcium ion import, cardiac muscle cell action potential involved in contraction, chemical synaptic transmission, membrane depolarization during action potential, neuronal action potential, positive regulation of calcium ion-dependent exocytosis, regulation of atrial cardiac muscle cell membrane depolarization, regulation of heart rate by cardiac conduction, regulation of ion transmembrane transport, response to nickel cation | Sperm storage76 |
| CAMK1D | Calcium/calmodulin dependent protein kinase 1D | Calcium signalling pathway. ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, protein serine/threonine kinase activity | Peptidyl-serine phosphorylation, negative regulation of apoptotic process, positive regulation of apoptotic process, CREB transcription factor activity, neuron projection development, neutrophil chemotaxis, phagocytosis and respiratory burst, regulation of dendrite development | 73 | |
| CNKSR2 | Connector enhancer of kinase suppressor of Ras 2 | Protein kinase binding | Intracellular signal transduction, regulation of signal transduction | 73 | |
| COL5A3 | Collagen alpha-1(XI) chain | ||||
| COLGALT1 | Collagen beta(1-O)galactosyltransferase 1 | Lysine degradation, O-glycan biosynthesis, metabolic pathways | Procollagen galactosyltransferase activity | Positive regulation of collagen fibril organization | Skin development77 |
| FGFR1 | Fibroblast growth factor receptor 1 | MAPK and calcium signalling pathway, adherens junction, regulation of actin cytoskeleton | ATP binding, fibroblast growth factor-activated receptor activity | Positive regulation of cell population proliferation | Tail regeneration78,79 |
| GPC1 | Glypican 1 | Copper ion binding, fibroblast growth factor binding, laminin binding | Cell migration, heparan sulfate proteoglycan catabolic process, negative regulation of fibroblast growth factor receptor signalling pathway, positive regulation of skeletal muscle cell differentiation, regulation of protein localization to membrane | 73 | |
| GPC4 | Glypican 4 | Wnt signalling pathway | Cell migration, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of presynapse assembly, regulation of protein localization to membrane, regulation of signal transduction, synaptic membrane adhesion, Wnt signalling pathway | Adipocyte differentiation80 | |
| HS6ST2 | Heparan-sulfate 6-O-sulfotransferase 2 | Glycosaminoglycan biosynthesis—heparan sulfate/heparin | Sulfotransferase activity | Cell proliferation and differentiation | Cell proliferation81 |
| ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 isoform X1 | Calcium signaling pathway, phosphatidylinositol signalling system, oocyte meiosis, apoptosis, cellular senescence, vascular smooth muscle contraction, apelin signalling pathway, Gap junction, NOD-like receptor signalling pathway, C-type lectin receptor signalling pathway, GnRH signalling pathway | Calcium ion binding, ion channel binding, phosphatidylinositol binding, scaffold protein binding | Cellular response to cAMP and ethanol, release of sequestered calcium ion into cytosol, response to hypoxia | Egg shell quality, muscle contraction, response to hypoxia82–84 |
| MAP2 | Microtubule associated protein 2 | Dystroglycan and microtubule binding | Axonogenesis, cellular response to organic substance, central nervous system neuron development, dendrite morphogenesis, establishment of cell polarity, microtubule bundle formation, microtubule cytoskeleton organization, negative regulation of axon extension, neuron projection development, regulation of cellular protein localization | Neuronal development85 | |
| MAP7D3 | MAP7 domain-containing protein 3 isoform X1 | Microtubule cytoskeleton organization | Sex determination86 | ||
| MYO18B | Myosin-XVIIIb | Actin and ATP binding, motor activity | 73 | ||
| MYO7B | Myosin VIIb | Actin-dependent ATPase activity, actin filament binding, ATP binding, microfilament motor activity | Actin filament organization, brush border assembly, sensory organ development, sensory perception of sound, vesicle transport along actin filament | 73 | |
| OLFM2 | Olfactomedin 2 | Positive regulation of smooth muscle cell differentiation, protein secretion | 73 | ||
| PBX3 | Pre-B-cell leukemia transcription factor 3 | DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific | Animal organ morphogenesis, brain development, embryonic organ development, eye development, neuron development, regulation of transcription by RNA polymerase II | Embryonic development87 | |
| PCDH17 | Protocadherin 17 | Calcium ion binding | Adult behaviour, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering | 73 | |
| PCDH7 | Protocadherin 7 | Calcium ion binding | Cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules | 73 | |
| TACC1 | Transforming acidic coiled-coil containing protein 1 | Estrogen receptor binding, glucocorticoid receptor binding, peroxisome proliferator activated receptor binding, retinoid X receptor binding, thyroid hormone receptor binding | Cell population proliferation, microtubule cytoskeleton organization, mitotic spindle organization, positive regulation of nuclear receptor transcription coactivator activity | 73 | |
| WNT10A | Protein Wnt-10a | mTOR and Wnt signalling pathway, melanogenesis | Signaling receptor binding | Multicellular organism development, Wnt signalling pathway | Tail regeneration, epidermis morphogenesis88 |
| ZNF516 | Zinc finger protein 516 | Activating transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding | Adipose tissue development, brown fat cell differentiation, positive regulation of cold-induced thermogenesis and transcription, response to cold | Thermogenesis89 | |
| ZNF711 | Zinc finger protein 711 | DNA binding, metal ion binding | Regulation of transcription | 73 |