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. 2020 Apr 14;217(6):e20190634. doi: 10.1084/jem.20190634

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Figure 1. — Loss of ACKR4 inhibits tumor growth in vivo. (A) Age of tumor onset for MMTV-PyMT B6 (Ackr4^+/+) and Ackr4^−/− mice; n = 31 (Ackr4^+/+), 14 (Ackr4^−/−), Mantel–Cox test. (B) Total weight of mammary glands in MMTV-PyMT B6 and Ackr4^−/−at 20 wk of age; n = 31 (Ackr4^+/+), 14 (Ackr4^−/−), unpaired t test. (C and D) Survival curve of WT and Ackr4^−/− mice inoculated with 25 µg (C) or 300 µg (D) MCA in the hind flank (C: n = 8, 20; D: n = 13, 8, Mantel-Cox test). (E and F) Growth curves (E) and weights (F) of WT or Ackr4^−/− mice injected with 10⁵ E0771 mammary carcinoma cells. Data in E and F are pooled from three independent experiments; n = 16–21 (E, two-way ANOVA; F, unpaired t test). Data are presented as mean ± SEM. *, P ≤ 0.05; ***, P ≤ 0.001.