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. 2020 Apr 14;217(6):e20190634. doi: 10.1084/jem.20190634

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Figure 3. — Loss of ACKR4 promotes intratumor DC accumulation. WT or Ackr4^−/− mice were injected with E0771 cells, and tumors were analyzed 18 d later. (A) Representative gating strategy for intratumoral DCs pregated on live CD45⁺ cells. FSC, forward scatter. (B–D) Frequency (of total viable cells) and number of intratumor (B) DCs (MHC-II⁺ CD11c⁺ Ly6C⁻), (C) CD103⁺ DCs, and (D) CD172a⁺ cDC2s. (E and F) Frequency and number of migratory (E) CD103⁺ DCs and (F) CD172a⁺ cDC2s in dLNs. Data are pooled from two independent experiments (B) or representative of at least two independent experiments (C–F); n = 6–10 mice, unpaired t test. Data are presented as mean ± SEM. *, P ≤ 0.05; **, P ≤ 0.01.